Clinical Research Directory

Inclusion Criteria: * Patient over the age of 18, hospitalized in the Orthopedics Department for a leg fracture (ankle, tibia: proximal, diaphysis, distal) requiring surgery within 72 hours of the trauma * Patient covered by the social security system * Patient giving informed consent Exclusion Criteria: * Open fracture with infectious risks cauchoix 2 and 3 * Multiple trauma, * Pathological fracture on primary or secondary lesions, * Pre-existing bone disease (excluding osteoporosis) of the operated limb, * Diabetes, * Pre-existing trophic disorders on one of the 2 lower limbs, * Long-term corticotherapy, * Pathology of the pituitary-adrenal axis, * Any other contraindication to glucocorticoids: any infectious condition, some developing viral diseases (including hepatitis, herpes, chicken pox, shingles), hypersensitivity to one of the constituents * Hypernatremia and hypochloremia * Pre-existing severe cardiac injury * Contraindication to TegadermTM * Patient placed under guardianship, tutorship or safeguard of justice, * Pregnant or lactating women,