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The RIPPLE AT-PLUS Study
Sponsor: Liverpool Heart and Chest Hospital NHS Foundation Trust
Summary
Atrial tachycardia is a symptomatic arrhythmia, for which an effective treatment is a catheter ablation procedure. The goal of the Ripple AT-Plus study is to evaluate two methods of performing catheter ablation for atrial tachycardia. The main outcome assessed during the study is long-term recurrence of atrial tachycardia following the catheter ablation procedure.
Official title: Isthmus Guided vs Anatomical Linear Ablation in the Treatment of Scar Related Atrial Tachycardia
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
201
Start Date
2022-08-16
Completion Date
2026-04
Last Updated
2025-09-25
Healthy Volunteers
No
Conditions
Interventions
Catheter ablation of atrial tachycardia: Ripple Mapping guided.
Ripple Mapping is used to map the atrial tachycardia mechanism. Using the scar thresholding technique the Ripple Map is interpreted and catheter ablation directed to the site of the heart identified as putative to the arrhythmia mechanism. All ablation lesions are confirmed to have conduction block across them using Ripple Mapping. This can include lesions created at previous ablation procedures.
Catheter ablation of atrial tachycardia: Conventional mapping guided.
Conventional activation mapping is used to map the atrial tachycardia mechanism. The resultant (activation) map is interpreted and ablation directed to the site of the heart identified as putative to the arrhythmia mechanism. All ablation lesions are confirmed to have conduction block across them using conventional mapping. This can include lesions created at previous ablation procedures.
Locations (3)
Liverpool Heart & Chest Hospital
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
Freeman Hospital, The Newcastle Upon Tyne NHS Foundation Trust
Newcastle, United Kingdom