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COMPLETED
NCT03918915
PHASE3

The Safety and Efficacy of SYD-101 in Children With Myopia

Sponsor: Sydnexis, Inc.

View on ClinicalTrials.gov

Summary

Myopia, or nearsightedness, is the most common eye disorder, often affecting more than 40% of adults in Europe, Asia and the USA. Severe myopia is associated with an increased risk of developing other eye conditions such as glucoma, cataracts and retinal detachment, which may lead to blindness. Early treatment of myopia in children could help slow the condition and minimize the risk of complications later in life. This study investigates the use of SYD-101, an eye solution, in slowing-down the progression of myopia in children.

Official title: A Multicenter, Randomized, Double-masked, Vehicle-controlled Study to Assess the Safety and Efficacy of SYD-101 Ophthalmic Solution for the Treatment of Myopia in Children

Key Details

Gender

All

Age Range

3 Years - 14 Years

Study Type

INTERVENTIONAL

Enrollment

852

Start Date

2019-04-24

Completion Date

2025-05-01

Last Updated

2026-07-30

Healthy Volunteers

No

Interventions

DRUG

SYD-101 0.01%

Sterile topical ophthalmic solution

DRUG

SYD-101 0.03%

Sterile topical ophthalmic solution

DRUG

Vehicle

Sterile topical ophthalmic solution without active ingredient

Locations (47)

Site 143

Irwindale, California, United States

Site 144

Pasadena, California, United States

Site 148

San Diego, California, United States

Site 104

San Diego, California, United States

Site 110

Santa Barbara, California, United States

Site 133

Sunnyvale, California, United States

Site 130

Colorado Springs, Colorado, United States

Site 100

Fort Collins, Colorado, United States

Site 102

Danbury, Connecticut, United States

Site 150

Waterbury, Connecticut, United States

Site 122

Fort Lauderdale, Florida, United States

Site 109

Jupiter, Florida, United States

Site 119

Sweetwater, Florida, United States

Site 120

Tamarac, Florida, United States

Site 124

Marietta, Georgia, United States

Site 116

Chicago, Illinois, United States

Site 106

Wilmette, Illinois, United States

Site 135

Indianapolis, Indiana, United States

Site 131

Munster, Indiana, United States

Site 137

Pittsburg, Kansas, United States

Site 138

Bangor, Maine, United States

Site 123

Boston, Massachusetts, United States

Site 114

Washington, Missouri, United States

Site 132

Henderson, Nevada, United States

Site 139

Albuquerque, New Mexico, United States

Site 127

Buffalo, New York, United States

Site 117

Chapel Hill, North Carolina, United States

Site 121

Raleigh, North Carolina, United States

Site 105

Fargo, North Dakota, United States

Site 111

Medford, Oregon, United States

Site 147

Tigard, Oregon, United States

Sie 136

Bala-Cynwyd, Pennsylvania, United States

Site 128

Cranberry Township, Pennsylvania, United States

Site 108

Charleston, South Carolina, United States

Site 126

Lakeway, Texas, United States

Site 142

San Antonio, Texas, United States

Site 101

San Antonio, Texas, United States

Site 115

The Woodlands, Texas, United States

Site 149

Ogden, Utah, United States

Site 140

Ogden, Utah, United States

Site 113

Virginia Beach, Virginia, United States

Site 204

Graz, Styria, Austria

Site 203

Linz, Upper Austria, Austria

Site 205

Vienna, Austria

Site 202

Bratislava, Slovakia

Site 201

Trebišov, Slovakia

Site 200

Trenčín, Slovakia