Clinical Research Directory

INCLUSION CRITERIA * ≥40 and ≤70 years of age * Resident in Scotland and have a Community Health Index (CHI) number * One or more of the following risk factors: * \>60 years of age * Current or recent (within 12 months) smoker * Clinical diagnosis of hypertension * Known hypercholesterolaemia or total cholesterol \>6.0 mmol/L or receiving statin therapy * Diabetes mellitus * Rheumatoid arthritis * Systemic lupus erythematosus (SLE) * Family history of premature cardiovascular disease (first degree relative with atherosclerotic cardiovascular disease below 60 years) * Chronic kidney disease stage 3 (estimate glomerular filtration rate 30-59 mL/min/1.73 m2). EXCLUSION CRITERIA * Inability to undergo CTCA * Known coronary heart disease or other major atherosclerotic cardiovascular disease * Prior invasive or non-invasive coronary angiography within the last 5 years * Chronic kidney disease stage ≥4 (estimate glomerular filtration rate \<30 mL/min/1.73 m2) * Known homozygous familial hypercholesterolaemia or other serious inherited disorders of lipid metabolism requiring statin therapy * Intolerance of all statins * Statin therapy for \>2 years. * Previous coronary artery imaging completed specifically for cardiovascular risk assessment with a result of \>10 AU.