Clinical Research Directory

Inclusion criteria for the irritable bowel syndrome group: 1. Subjects fulfill Rome IV diagnostic criteria for irritable bowel syndrome and pain frequency for at least 1 day per week in the last 12 weeks 2. Males or females aged 18-65 years 3. Signed informed consent Exclusion criteria for the irritable bowel syndrome group: 1. Concurrent or recent treatment with drugs affecting intestinal microbiota, function or mood, e.g., antidepressants (\< 12 weeks), antibiotics (\< 12 weeks) 2. Concurrent or recent (\< 4 weeks) use of nutritional supplements or herb products affecting intestinal function or mood (e.g. aloe vera, St. John´s Wort and probiotics) 3. Diagnosis of major psychiatric or somatic disease other than part of irritable bowel syndrome 4. Suicidal tendencies according to Montgomery Åsberg Depression Ratings Scale and/or clinical judgment 5. Abuse of alcohol or drugs according to Alcohol Use Disorders Identification Test, and/or clinical judgment 6. Recent (\< 4 weeks) intake of proton pump inhibitors (e.g., omeprazole) 7. Epilepsy 8. Cerebral bleeding or history of cerebral bleeding 9. Pregnancy or breastfeeding (will be asked) 10. Claustrophobia 11. Smoking or using tobacco including snuff 12. Dominant left-hand 13. Medical implant (e.g., pacemaker) 14. Aneurysm clips in the head 15. Shunts in the head 16. Grenade-splinter or metal-splinter in the body (e.g., eyes) 17. Metal or electrodes in the body (e.g., temp-catheter, aorta stent, cochlear implant) 18. Comprehensive tooth-implants or prothesis 19. Operated in the head 20. Operated in the heart 21. Swallowed a video-capsule 22. Non-corrected astigmatism 23. Regular intake of antiinflammatory medication (including non-steroidal antiinflammatory drugs) 24. Visual defect without possibility to use lenses during functional magnetic resonance imaging scanning 25. Any other reason the investigator feels the subject is not suitable for participation in the study Inclusion criteria for healthy group: 1. Males and females aged 18-65 years of age 2. Signed informed consent Exclusion criteria for the healthy group: 1. Concurrent or recent history of gastrointestinal disorders or any somatic disorder 2. Concurrent or recent treatment with drugs affecting intestinal microbiota, function or mood, e.g., antidepressants (\< 12 weeks), antibiotics (\< 12 weeks) 3. Concurrent or recent (\< 4 weeks) use of nutritional supplements or herb products affecting intestinal function or mood (e.g. aloe vera, St. John´s Wort and probiotics) 4. Concurrent psychiatric or psychological symptomatology defined as above cut-off on Montgomery Åsberg Depression Ratings Scale, above clinical cut-off on hospital anxiety and depression scale (equal to or above 8) 5. Abuse of alcohol or drugs according to Alcohol Use Disorders Identification Test, and/or clinical judgment 6. Recent (\< 4 weeks) intake of proton pump inhibitors, (e.g., omeprazole) 7. Epilepsy 8. Cerebral bleeding or history of cerebral bleeding 9. Pregnancy or breastfeeding (will be asked) 10. Claustrophobia 11. Smoking or using tobacco including snuff 12. Dominant left-hand 13. Medical implant (e.g., pacemaker) 14. Aneurysm clips in the head 15. Shunts in the head 16. Grenade-splinter or metal-splinter in the body (e.g., eyes) 17. Metal or electrodes in the body (e.g., temp-catheter, aorta stent, cochlear implant) 18. Comprehensive tooth-implants or prothesis 19. Operated in the head 20. Operated in the heart 21. Swallowed a video-capsule 22. Non-corrected astigmatism 23. Intake of anti-inflammatory medication (including non-steroidal antiinflammatory drugs) 24. Visual defect without possibility to use lenses during functional magnetic resonance imaging scanning 25. Any other reason the investigator feels the subject is not suitable for participation in the study.