Clinical Research Directory

Participant-Related Inclusion Criteria: I. All Diabetics (Groups A, B, C) * Type 1 diabetes of at least 5 years duration or * Type 2 diabetes of any duration II. Group B * Able to return for follow-up over 3 years Participant-Related Exclusion Criteria: I. Group B * Significant medical condition that would make long-term follow-up difficult II. Controls (Group D) * Any medical problems associated with retinal vascular abnormalities (i.e., hypertension, systemic vasculitis, carotid insufficiency, etc.) Eye-Related Inclusion Criteria: I. Group A: * Presence of active neovascularization, with or without prior treatment * Presence of involuted fibrovascular proliferans II. Group B: * NPDR of any severity as defined by the International Clinical Diabetic Retinopathy Severity Scale III. Groups C \& D: * No evidence of diabetic retinopathy IV. Group ME: * Presence of center-involving macular edema requiring treatment Eye-Related Exclusion Criteria: (Applies to study eye only. May be present in non-study eye.) * Visual acuity worse than 20/200 * Inability to maintain stable fixation for OCT imaging * History of major eye surgery (vitrectomy, cataract surgery, scleral buckle, other intraocular surgery, etc.) within 90 days of enrollment * History of another eye disease or condition that may alter retinal perfusion, permeability, or retinal anatomy * Substantial media opacity (cataract, corneal scar, vitreous hemorrhage) that may interfere with study imaging