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Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal Cancer
Sponsor: University Medical Center Groningen
Summary
In this study the characteristics and alterations of the gut microbiome during chemotherapy for metastasized or irresectable CRC are studied, as well as the relation between the gut microbiome and the effects of chemotherapy.
Official title: Gut Microbiome Dynamics in Metastasized or Irresectable Colorectal Cancer: Initiating a Prospective Multicenter Cohort (GIMICC)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2020-09-09
Completion Date
2026-01
Last Updated
2025-01-01
Healthy Volunteers
No
Conditions
Interventions
fecal sample
patients will collect fecal samples at home prior to treatment and at 3 months after start of treatment at the time of response evaluation using a standard stool-collection-kit.
questionnaire
At the day of stool sampling, patients fill out a brief questionnaire about established factors that can change the microbiome such concurrent use of antibiotics and proton pump inhibitors.
Blood sample
4 tubes of blood are collected prior to treatment and at 3 months after start of treatment at the time of response evaluation and sent to the UMCG for storage.
Locations (10)
Wilhelmina Ziekenhuis
Assen, Netherlands
Ziekenhuis Nij Smellinghe
Drachten, Netherlands
Treant Zorggroep
Emmen, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Martini Ziekenhuis
Groningen, Netherlands
Tjongerschans Ziekenhuis
Heerenveen, Netherlands
Medisch Centrum Leeuwarden
Leeuwarden, Netherlands
Ommelander Ziekenhuis Groep
Scheemda, Netherlands
Antonius Zorggroep
Sneek, Netherlands