Clinical Research Directory
Browse clinical research sites, groups, and studies.
Single Dose Liposomal Amphotericin for Asymptomatic Cryptococcal Antigenemia
Sponsor: Makerere University
Summary
This will be a randomized controlled trial of asymptomatic (Cryptococcal Antigen test)CrAg positive persons in Uganda. Patients will be randomized to receive preemptive treatment with 1 dose of liposomal amphotericin (10mg/kg) in addition to standard of care fluconazole therapy. How the enhanced antifungal therapy prevents progression to meningitis in the first 24-weeks and overall survival in those who receive the intervention compared with participants receiving fluconazole per World Health Organisation (WHO) and national standard of care therapy will be evaluated.
Official title: Evaluation of CrAg Screening With Enhanced Antifungal Therapy for Asymptomatic CrAg+ Persons
Key Details
Gender
All
Age Range
15 Years - Any
Study Type
INTERVENTIONAL
Enrollment
356
Start Date
2019-06-20
Completion Date
2028-04
Last Updated
2023-04-12
Healthy Volunteers
No
Conditions
Interventions
Single dose liposomal Amphotericin and Fluconazole
Intravenous Single dose of 10mg/kg of Ambisome and fluconazole as per WHO guidelines for six months.
Fluconazole
Fluconazole 800mg for 2 weeks,400mg for 8 weeks and 200mg up to six months
Locations (1)
infectious Disease Institute Kampala,Uganda
Kampala, Uganda