Clinical Research Directory

Inclusion Criteria: * A diagnosis of a Serious Mental Illness (SMI)\* * 18 years and older * Smoking at least five cigarettes per day for the past 6 months * Willingness to set a quit date * Not currently taking bupropion or using nicotine replacement therapy (NRT) * Current participant in the residential or day treatment program at a Progress Foundation program with the intention to continue in the residential or day treatment program for at least the 12 week intervention period * Capacity to consent. * SMI is characterized by the American Psychological Association as distinct conditions that require routine management, produce functional impairment, and interfere with quality of life. Individuals that typically meet the criteria of SMI have illnesses that include schizophrenia, schizoaffective disorder, psychotic disorders, major depressive disorders, bipolar disorders, and borderline personality disorder. Exclusion Criteria: * Currently pregnant or breastfeeding * Diagnosis of seizure disorder, history of anorexia/bulimia, undergoing abrupt discontinuation of ethanol or sedatives, other conditions that increase seizure risk (e.g., arteriovenous malformation (AVM), severe head injury, central nervous system (CNS) tumor) * use of Monoamine oxidase (MAO) inhibitors (concurrently or within 14 days of discontinuing either bupropion or the MAO inhibitor) * Planning to become pregnant during the study period * Previous participation in the videogame-based physical activity intervention. * Known medical conditions or other physical problems that need special attention in an exercise program (e.g. prior myocardial infarction, uncontrolled hypertension, history of angioplasty, history of angina, use of nitroglycerin to treat angina)