Clinical Research Directory

Inclusion Criteria: * Fulfills current DSM-5 (American Psychiatric Association Diagnostic and statistical manual of mental disorders, 5th ed, 2013) diagnostic criteria for OUD (severe) and at least a 5-year history. * Participants may have comorbid SUD diagnoses at mild, moderate or severe levels, however OUD must be the primary disorder for which the individual is seeking treatment and the other use disorders must occur in the context of relapse * Failed at least two levels of treatment (outpatient/Comprehensive Opioid Addiction Treatment (COAT), intensive outpatient/intensive COAT, residential, inpatient, Adult Intensive Outpatient Program (AIOP), Dual Diagnosis Unit (DDU), which included buprenorphine/naloxone. * At least two overdose survivals or one overdose survival and one life-threatening infectious disease complication with relapse after treatment (e.g., endocarditis with valve repair/replacement) within the past 1 year. * Family/Social Support/Involvement (as assessed via the Multidimensional Scale of Perceived Social Support). * Is able to provide informed consent. Exclusion Criteria: * Medical problems requiring intensive medical or diagnostic management. * Diagnosis of acute myocardial infarction or cardiac arrest within the previous 6 months. * History of a neurosurgical ablation procedure. * Any medical contraindications to undergoing DBS surgery. * History of hemorrhagic stroke. * Life expectancy of \<3 years * Past or present diagnosis of schizophrenia, psychotic disorder, bipolar disorder, or untreated depression other than one determined to be substance induced (assessed via SCID-5). Any treated depression has to have been in remission for one year. * Baseline assessment on the Hamilton Depression Rating Scale (HAMD) of greater than 17 or increased risk of suicide based upon any positive response on the Columbia Suicide Severity Scale. * Cluster A or B Personality Disorders. * Diagnosis of dementia. * History of neurological disorder. * History of previous neurosurgery (brain) or head trauma. * History of suicide attempt. * Parental history of completed suicide. * Abnormal coagulation lab studies or uncontrolled hypertension. * Implanted neurostimulators. * Any current CNS infection or infection with the Human Immunodeficiency Virus (HIV). * Unable to undergo MR-imaging. * Documentation of MRI abnormality indicative of a neurological condition. * Substance abuse treatment mandated by court of law. * Pregnant or planning to become pregnant. * Conditions requiring diathermy. * Anticoagulant treatment. * Primary language other than English. * Any evidence of systemic infection.