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Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy
Sponsor: Wake Forest University Health Sciences
Summary
This pilot clinical trial studies how well ultrasound works in detecting oxaliplatin-induced neuropathy in participants with gastrointestinal cancer. Ultrasound may work better in diagnosing and detecting neuropathy in gastrointestinal cancer participants treated with the chemotherapy drug called oxaliplatin.
Official title: A Pilot Study Using Ultrasound for the Detection of Oxaliplatin-Induced Peripheral Neuropathy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2019-12-17
Completion Date
2025-11-26
Last Updated
2026-07-20
Healthy Volunteers
No
Conditions
Interventions
Ultrasound - Serial and Tibial Nerve
Participants will undergo a serial and tibial nerve ultrasound
Skin Biopsy
Two skin biopsies will be obtained as 4.0 mm punch biopsies at distal end of leg in sural nerve territory (10 cm above lateral malleolus) and from the thigh
Abbreviated Neurologic Exam
Exam to include strength assessment of the tibialis anterior and gastrocnemius and deep tendon reflex exam of the Achilles on the limb to be examined by nerve conduction velocity and ultrasound.
Blood draw
12 ml blood sample will be taken
Nerve Conduction Study
Sural and tibial nerve assessments
QLQ-CIPN20 Questionnaire Administration
Self-reported neuropathy scoring questionnaire completed same day as blood draw.
Locations (1)
Wake Forest Baptist Comprehensive Cancer Center
Winston-Salem, North Carolina, United States