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Evolution of Oropharyngeal and Rectal Microbiota After Severe Traumatic Brain Injury
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Modifications of the human gut microbiota have been associated with different pathological conditions such as obesity, inflammatory bowel diseases and neurodegenerative diseases. Recently the " Brain-Gut Axis ", a bidirectional communication axis between brain and gut, has been described. In recent animal studies, an acute brain injury was associated with rapid modifications of the gut microbiota. In humans, traumatic brain injury (TBI) is a leading cause of death and disability. The patterns of gut and oropharyngeal microbiota following TBI are unknown. The primary purpose of this study is to characterize gut and oropharyngeal microbiota of patients with severe TBI.
Official title: From the Brain to the Bugs: Evolution of Oropharyngeal and Rectal Microbiota of Patients With Severe Traumatic Brain Injury Admitted in ICU
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
58
Start Date
2019-04-21
Completion Date
2024-12
Last Updated
2024-05-30
Healthy Volunteers
Yes
Conditions
Interventions
Oropharyngeal swab
Will be performed by trained paramedical staff using sterile swabs with transport medium ESwab® (Becton, Dickinson and Company, New Jersey, USA). Swabs will be stored at -80°C until DNA extraction.
Rectal swab
Will be performed by trained paramedical staff using sterile swabs with transport medium ESwab® (Becton, Dickinson and Company, New Jersey, USA). Swabs will be stored at -80°C until DNA extraction.
Disability rating scale (DRS-F)
Will be assessed at day 90 +/- 7 days.
Locations (1)
APHP Bicêtre Hospital
Le Kremlin-Bicêtre, France