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Evolution of Tophus and Erosions of Hands and Feet at DECT
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
The main objective is to evaluate the decrease in crystalline volume of the target tophus using Dual-Energy Computed Tomography (DECT), after 6 months +/- 1 month of urate-lowering therapy with target uricemia. Study hypothesis * The dynamics of tophus resolution with urate-lowering therapy is poorly understood. * It is variable according to the location of the tophus, peri articular / intratendinous, but also probably at the feet / hands, the initial overall volume of the tophus, the initial crystal charge of the tophus. Knowledge of prognostic factors for tophus resolution will help determine the best target for treatment follow-up for each patient. * Erosions are the consequence of tophus. Tophus resolution could be associated with repair of erosions and stabilization of joint destruction.
Official title: Evolution of Tophus and Erosions of Hands and Feet With Urate-lowering Therapy: Prospective Study Using Dual-Energy Computed Tomography
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2019-07-24
Completion Date
2025-10-11
Last Updated
2025-09-12
Healthy Volunteers
No
Conditions
Interventions
Dual-Energy Computed Tomography examination
Dual-Energy Computed Tomography examination at 6 and 12 months +/- 1 month of medical treatment with uricemia \< 360μmol/L (baseline DECT is in the domain of usual care).
Locations (2)
Radiology Department Lariboisière Hospital
Paris, Île-de-France Region, France
Reumatology Department Lariboisière Hospital
Paris, Île-de-France Region, France