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Intralipid® 20% for Reversal of Local Anesthetics
Sponsor: Hospital for Special Surgery, New York
Summary
In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits. Small amounts of local anesthetics will be injected into the volunteers' thighs during both visits. During one visit volunteers will receive Intralipid 20% and during the other visit they will receive a saline solution. The study team will measure how quickly normal sensation returns to the thighs when the volunteers get Intralipid 20% compared to saline.
Official title: The Use of Intralipid® 20% Solution to Reverse the Anesthetic Effect of Local Anesthetics: a Proof of Concept Study in Volunteers
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
18
Start Date
2019-07-26
Completion Date
2026-10
Last Updated
2025-12-08
Healthy Volunteers
Yes
Conditions
Interventions
Lidocaine 2%
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Lidocaine 1%
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Bupivacaine 0.25%
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Bupivacaine 0.5%
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Intralipid, 20% Intravenous
a 250ml bag administered intravenously
Saline intravenously
a 250ml bag administered intravenously
Saline
3 mL of test solution to a skin area on the thigh, 2cm in diameter
Locations (1)
Hospital of Special Surgery
New York, New York, United States