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Improving Sleep, Sleep-related Outcomes, and Biomarkers in Veterans
Sponsor: Portland VA Medical Center
Summary
The primary purpose of this project is to determine the effect of morning bright light therapy (MBLT) on sleep in Veterans with traumatic brain injury (TBI). Secondarily, the project aims to identify blood-based brain biomarkers (BBBM) associated with sleep in Veterans. Specific Aim 1. Determine the effect of MBLT on sleep quality in Veterans (primary outcome). Specific Aim 2. Determine the effect of MBLT on downstream effectors of improved sleep, including cognition, mood, and quality of life measures in Veterans (exploratory outcomes). Specific Aim 3. Determine the effect of MBLT on levels of specific BBBM related to sleep, and whether changes in specific BBBM predict response to MBLT (secondary outcome). This study can now be completed 100% remotely.
Key Details
Gender
All
Age Range
18 Years - 88 Years
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2019-08-01
Completion Date
2025-12-01
Last Updated
2025-11-14
Healthy Volunteers
Yes
Conditions
Interventions
Light box therapy
The intervention is sitting in front of a lightbox for 1 hour in the morning upon waking up.
Negative Ion Generator
The intervention is sitting in front of a modified negative ion generator for 1 hour in the morning upon waking up.
Locations (1)
Portland VA Medical Center
Portland, Oregon, United States