Clinical Research Directory

Inclusion Criteria: * Age: ≥12 months and \<18 years * Has a major sickle cell disease whatever the genotype * Admission to hospital for a febrile vaso-occlusive crisis (VOC) or not * Evolving at home for less than 48h * Concomitant treatment with hydroxycarbamide / hydroxyurea possible * Signed consent * Patients affiliated to a French social security scheme Exclusion Criteria: * Child presenting an acute thoracic syndrome (ATS) from the outset at the admission * Child who presented an ATS in the month preceding the inclusion * Child in regular transfusion program or child who has received a hematopoietic stem cell transplant * Child hospitalized at least 5 times for VOC in the year preceding inclusion (psychic problems making difficult the evaluation of the pain) * Child who has already been included in the study during a previous VOC (each child participates in the study only once) * VOC evolving for more than 48 hours before admission to the emergency room * Acute splenic sequestration crisis at admission