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Neuroendocrine Risk for PTSD in Women
Sponsor: Emory University
Summary
This study will test for effects of estradiol (E2) on PTSD symptoms and functional magnetic resonance imaging (fMRI) indicators of stress vulnerability, in naturally-cycling women who are not using hormonal birth control. Enrollment will be targeted to create three groups within two cohorts (early follicular phase and luteal phase): 1. PTSD: Women who meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for PTSD 2. Trauma-Exposed (TC): Women matched for age and trauma exposure severity but without PTSD 3. Healthy Control (HC): Women matched for age, but without trauma history or psychiatric disorder (self-reported) Women will be recruited through Grady Trauma Project (GTP), a large longstanding study of civilian trauma and PTSD conducted at Grady Memorial Hospital in Atlanta, Georgia.
Official title: The LOW E2 STUDY- Neuroendocrine Risk Mechanisms for Post-traumatic Stress Disorder in Women
Key Details
Gender
FEMALE
Age Range
18 Years - 35 Years
Study Type
INTERVENTIONAL
Enrollment
127
Start Date
2019-11-11
Completion Date
2025-04-30
Last Updated
2026-07-22
Healthy Volunteers
No
Interventions
Estradiol patch
Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.
Placebo patch
Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.
Locations (1)
Grady Memorial Hospital
Atlanta, Georgia, United States