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Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms
Sponsor: Centre Hospitalier Universitaire de Nīmes
Summary
Automated immunodosage methods (Roche Elecsys cortisol and IDS cortisol dosing kits) offer a simple and inexpensive technology routinely used in a medical biology laboratory. They can be used to define robust diagnostic thresholds for salivary cortisol for the diagnosis of Cushing's syndrome and pseudo-Cushing combining the three tests performed as part of the patient's usual management. (ie two urinary free cortisol (UFC), the dexamethasone suppression test, and Diurnal variation of plasma cortisol).
Official title: Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms: Phase III Diagnostic Evaluation Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
380
Start Date
2019-07-01
Completion Date
2026-07
Last Updated
2025-11-17
Healthy Volunteers
Not specified
Conditions
Interventions
Blood test
Plasma cortisol level test
24-hour Urine test
Urinary free cortisol test
Saliva swab
salivette® for salivary cortisol quantification
Dexamethasone test
Dectancyl® 2 x 0.5 mg tablets (total 1 mg)
Locations (1)
CHU de Nimes
Nîmes, France