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ACTIVE NOT RECRUITING
NCT03974789

Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms

Sponsor: Centre Hospitalier Universitaire de Nīmes

View on ClinicalTrials.gov

Summary

Automated immunodosage methods (Roche Elecsys cortisol and IDS cortisol dosing kits) offer a simple and inexpensive technology routinely used in a medical biology laboratory. They can be used to define robust diagnostic thresholds for salivary cortisol for the diagnosis of Cushing's syndrome and pseudo-Cushing combining the three tests performed as part of the patient's usual management. (ie two urinary free cortisol (UFC), the dexamethasone suppression test, and Diurnal variation of plasma cortisol).

Official title: Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms: Phase III Diagnostic Evaluation Study

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

380

Start Date

2019-07-01

Completion Date

2026-07

Last Updated

2025-11-17

Healthy Volunteers

Not specified

Conditions

Interventions

DIAGNOSTIC_TEST

Blood test

Plasma cortisol level test

DIAGNOSTIC_TEST

24-hour Urine test

Urinary free cortisol test

DIAGNOSTIC_TEST

Saliva swab

salivette® for salivary cortisol quantification

DIAGNOSTIC_TEST

Dexamethasone test

Dectancyl® 2 x 0.5 mg tablets (total 1 mg)

Locations (1)

CHU de Nimes

Nîmes, France