Inclusion Criteria:
* Age ≥ 50 years
* History of diabetes, defined as medical record evidence or patient report of currently using insulin or oral hypoglycemic agents, or with a history of fasting blood glucose measurement of 126 mg/dL or higher, or a history of HbA1c of 6.5% or higher.
* Significant stenosis (≥ 75%) of two or more infra-popliteal arteries in the affected limb as verified by at least one imaging technique (angiography, magnetic resonance angiogram, coronary computed tomography angiogram, or doppler examination) within 6 months prior to enrollment;
* History of CLI defined as moderate or high-risk infra-popliteal chronic critical limb ischemia (Rutherford Clinical Severity Score 4 or 5) defined as:
* The presence of rest pain or non-healing ulceration or gangrene for at least 2 weeks plus documentation of severely compromised tissue perfusion:
* If there is tissue loss, a resting ankle systolic pressure of ≤ 60 mmHg in the affected limb; or a resting toe systolic pressure of ≤ 40 mmHg or a tissue perfusion pressure (TPP) \<40 mmHg.
* If there is no tissue loss, a resting ankle pressure of ≤ 50 mmHg or resting toe systolic pressure of ≤ 30 mmHg or a tissue perfusion pressure (TPP) \< 30 mmHg.
* Not a candidate or a failed candidate for surgical or transcatheter revascularization;
* Able to give informed consent.
Exclusion Criteria:
* \<7 days following lower extremity (infra-popliteal), carotid, or coronary revascularization.
* Arterial insufficiency in the lower extremity as the result of a non-atherosclerotic disorder.
* Subjects with evidence of active infection (e.g., cellulitis, osteomyelitis) or deep ulceration exposing bone or tendon or extensive heel ulceration
* Subjects with extensive gangrene extending above the MT joint
* Subjects in whom there is severe pain at rest uncontrollable with pain medications
* Prior intravenous chelation therapy consisting of \> 1 infusion within 5 years; if only 1 infusion took place, patient cannot be enrolled for at least 12 months after said infusion.
* Oral chelation with an FDA-approved chelating agent within 2 years
* Allergy to any components of the study drug
* Planned leg revascularization within 1 month of enrollment
* Symptomatic or clinically evident acute heart failure
* Heart failure hospitalization within 3 months
* Blood pressure \>160/100
* No venous access
* eGFR \< 30 mL/min per 1.73 m2 or lower (CKD stages 1-3) calculated with MDRD
* Known or suspected acute kidney injury using prevalent KDIGO criteria45
* Platelet count \<100,000/mm3
* Cigarette smoking within the last 3 months
* Liver disease or Alanine aminotransferase (ALT), aspartate aminotransferase (AST) \> 2.0 times the upper limit of normal (this will require clearance by the Study PI)
* Diseases of copper, iron, or calcium metabolism (other than osteopenia or osteoporosis, or simple iron deficiency). These require evaluation by the Study PI
* Inability to tolerate the study-required fluid load
* Other medical condition likely to affect patient survival within 3 years
* Women of child-bearing potential
* Any factor that suggests that the potential participant will not be able to adhere to the protocol.
