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RECRUITING
NCT03983603
NA

Plant Stanol Esters and Preventing Asthma Symptoms

Sponsor: Maastricht University Medical Center

View on ClinicalTrials.gov

Summary

Plant stanols are known to lower low-density lipoprotein cholesterol. However, studies have suggested that these compounds also influence the immune system. Asthmatic responses are predominantly T helper (Th)2 cell dependent, while plant stanols were previously found to activate Th1 cells and shift the immune response away from the Th2 cell dominant asthmatic response. The question now is whether this also translates into a reduction of clinical symptoms in asthma patients.The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols modulate the immune system and to evaluate the effects of plant stanol ester consumption on cardiovascular (CVD) risk parameters.

Official title: The Effects of Long-term Daily Plant Stanol Ester Intake on Clinical Symptoms in Individuals With Allergic Asthma: an Exploratory Double-blind Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

160

Start Date

2019-04-29

Completion Date

2026-09

Last Updated

2026-06-25

Healthy Volunteers

No

Interventions

DIETARY_SUPPLEMENT

Soft chews containing 0.5g plant stanols (delivered as plant stanol esters)

Soft chews containing 0.5g plant stanols delivered as plant stanol esters

DIETARY_SUPPLEMENT

Placebo soft chew

Soft chew that does not contain plant stanols

Locations (1)

Maastricht University Medical Center

Maastricht, Limburg, Netherlands