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Plant Stanol Esters and Preventing Asthma Symptoms
Sponsor: Maastricht University Medical Center
Summary
Plant stanols are known to lower low-density lipoprotein cholesterol. However, studies have suggested that these compounds also influence the immune system. Asthmatic responses are predominantly T helper (Th)2 cell dependent, while plant stanols were previously found to activate Th1 cells and shift the immune response away from the Th2 cell dominant asthmatic response. The question now is whether this also translates into a reduction of clinical symptoms in asthma patients.The primary objective of this study is to demonstrate clinical benefits of prolonged consumption of plant stanols (delivered via plant stanol esters) in asthma patients. The secondary objectives are to evaluate the mechanisms via which plant stanols modulate the immune system and to evaluate the effects of plant stanol ester consumption on cardiovascular (CVD) risk parameters.
Official title: The Effects of Long-term Daily Plant Stanol Ester Intake on Clinical Symptoms in Individuals With Allergic Asthma: an Exploratory Double-blind Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2019-04-29
Completion Date
2026-09
Last Updated
2026-06-25
Healthy Volunteers
No
Conditions
Interventions
Soft chews containing 0.5g plant stanols (delivered as plant stanol esters)
Soft chews containing 0.5g plant stanols delivered as plant stanol esters
Placebo soft chew
Soft chew that does not contain plant stanols
Locations (1)
Maastricht University Medical Center
Maastricht, Limburg, Netherlands