Clinical Research Directory

Inclusion Criteria: * Mild TBI (GCS 13-15 on ED admission) with one of the following: * Patient with minor cerebral lesion on initial CT scan (TCDBII i.e. no midline shift, visible basal cisterns and haemorrhagic lesion \< 25 cc) and GCS 15 after CT scan * OR \* Patient with normal initial CT scan (TCDB I) with at least one risk factor : * GCS = 14 after CT scan * and/or alcoholic intoxication * and/or on-going treatment with anticoagulants or anti-platelet therapy * and /or persisting nausea, and/or vomiting and/or headaches * Early initial CT scan (\< 4 hours after TBI) * Possibility of home supervision by a third-party * Affiliation to the French social security system * Patient have signed consent form * Possibility to perform a TCD within 12 hours * Stable hemodynamics defined as a blood pressure greater than 90 mmHg, an SpO2 greater than 92% and a hemoglobin concentration greater than 8g/dl, or, in the absence of measured physiologic parameters or the absence of biological sampling, mention in the patient's medical record of a stable clinical examination in terms of hemodynamics and respiratory function. Exclusion Criteria: * CT scan classified as TCDB III - VI * Penetrating head-trauma * Patient under mechanical ventilation * Patients treated with anticoagulants or anti-platelet therapy (except Aspirin) * Hospitalization required by post-traumatic extra-cranial lesion, intoxication (except alcoholic), pre-existing condition (including congenital hemostasis disorders) or social factors at the discretion of the physician. * Internal Carotid dissection * Post-traumatic lesion in the posterior cerebral fossa * Subject in exclusion period of another interventional study, * Pregnant women, breastfeeding women * Subject under administrative or judicial control, under protection