Clinical Research Directory

Inclusion Criteria: * \>18 years; * unilateral lymphedema of the arm lymph node dissection * lymphedema onset less than a year before the therapy starts * lymphedema defined as \>3% volume difference between both arms * lymphedema stage 1, stage 2a or stage 2b * absence of pregnancy at the time of enrollment and willingness to use adequate contraceptive measures until the end of the study; * oral and written approval of the informed consent presented at the time of the consultation by the physicians; * understanding Dutch Exclusion Criteria: * \<18 years; * edema of the limb with different etiology or later stage/onset as specified in the inclusion criteria; * presence of active cancer * pregnancy or active breastfeeding; * impossibility to participate for the entire study period; * mentally or physically unable to participate to the study; * presence of gastrointestinal intolerance or other serious illness (e.g. renal failure, hepatic dysfunction, heart failure, neurological impairment); * presence of diabetes or other metabolic disease; * contra-indication for the use of indocyanine green (ICG): allergy to ICG or iodine, hyperthyroidism.