Clinical Research Directory

Inclusion Criteria recipient: * Age ≥18 years * Signed informed consent form * Listed for heart transplantation Inclusion criteria donor: * Age ≥18 and ≤70 years * Accepted as heart donor by the transplant team * (Research consent from the donor if required in country) Exclusion Criteria recipient: * Previous solid organ transplantation * Grown-up congenital heart disease (GUCH) * Kidney failure eGFR\<40 at listing, calculated by CDK-EPI Creatinine, or ultrafiltration or dialysis or rapidly deteriorating kidney function due to a diagnosed renal disease * Coagulopathy due to known hepatic disease or heparin induced thrombocytopenia * Subject diagnosed with Systemic Lupus Erythematous, sarcoidosis or amyloidosis * Known ongoing septicemia defined as positive blood culture immediately prior to the transplant (including with a durable VAD) * Incompatible blood group * Not able to understand the information provided during the informed consent procedure * Combined organ transplantation candidates * Subject already enrolled in another transplant related intervention study * Subjects under pre-transplant desensitization protocol (including plasma exchange in conjunction with the transplant surgery) * Mechanical circulatory support pre-transplantation (except durable Left ventricular assist device or Intra-aortic balloon pump) Exclusion criteria donor: * Previous sternotomy * DCD hearts