Clinical Research Directory

Inclusion Criteria: * i. Able to read and sign an Informed Consent Form (ICF) * ii. At least Age 18 * iii. Diagnosis of Asthma with previous source documentation of PC 20 ≤ 16 mg/dl measured by FEV1 and/or reversibility with albuterol of ≥12% in FEV1 * iv. pre-bronchodilator Forced Vital Capacity (FVC) less than 85% predicted AND Serum total MMP9 ≥ 1800 (cut off determined by previous clinical investigation- Medimmune) OR serum IL-8\> 20 pg/ml OR Sputum extracellular DNA ≥ 3.8 µg/mL OR Sputum Neutrophils \> 40% Exclusion Criteria: * i. Pregnancy * ii. Current smoker, smoking within the past year or pack/year history ≥ 10 * iii. Respiratory infection within past 6 weeks * iv. Antibiotics within the past 4 weeks * v. Active lung disease other than asthma * vi. Cancer within the past 5 years (excluding basal cell skin cancer) * vii. Chronic infection due to HIV, HBV, or HCV * viii. Hematologic or autoimmune disease * ix. Unable to safely undergo bronchoscopy as determined by primary or study doctor.