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SV2 PET Imaging With [11C]APP311
Sponsor: Yale University
Summary
The aim of this study is to evaluate a new SV2A tracer, \[11C\]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.
Official title: Synaptic Density in Psychiatric Disorders Using SV2A Receptor PET Imaging With [11C]APP311
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2017-12-01
Completion Date
2026-12
Last Updated
2026-01-28
Healthy Volunteers
Yes
Interventions
[11C]APP311
It has been shown that radiotracer \[11C\]APP311 (aka \[11C\]UCB-J) displays high specificity and selectivity for the synaptic vesicle protein SV2A. Since this protein is expressed ubiquitously in active synapses, this tracer has the potential to be a general purpose tool for quantitative imaging of synaptic density.
Locations (1)
Conneticut Mental Health Center
New Haven, Connecticut, United States