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ACTIVE NOT RECRUITING
NCT03998527
NA

Non-Invasive Spinal Cord Stimulation After Injury

Sponsor: University of Louisville

View on ClinicalTrials.gov

Summary

The goal of this study is to assess the function of the lungs and the muscles are used to breathe after individuals receive respiratory training, spinal cord stimulation, a combination of respiratory training and stimulation, a combination of arm training and stimulation, or a combination of trunk training and stimulation. The respiratory, arm, and trunk training combined with the spinal stimulation interventions are being used to activate the spinal cord below the level of injury. Investigators will be looking for changes in the function of the lungs and trunk muscles before, during, and after these task-specific and non-task-specific interventions for breathing to determine which one has the greatest effect. The results of this study may aid in the development of treatments to help individuals with spinal cord injuries that have impaired lung, arm, and trunk function.

Official title: Non-Invasive Spinal Cord Stimulation and Respiratory Plasticity

Key Details

Gender

All

Age Range

18 Years - 99 Years

Study Type

INTERVENTIONAL

Enrollment

36

Start Date

2018-05-17

Completion Date

2029-12-31

Last Updated

2026-03-13

Healthy Volunteers

Yes

Interventions

DEVICE

Transcutaneous Electrical Spinal Cord Stimulation (TcESCS)

TcESCS is a non-invasive DC battery powered device. Investigators and/or research team members will continually assess the appropriate stimulation parameters including configurations, current, voltage and frequency delivered by up to five active electrodes applied on skin of the back from cervical to lumbar levels. Stimulation parameters used during experimental assessments and interventions will be closely monitored by the research team. Every research participant will be slowly acclimated to stimulation. Blood pressure, heart rate, respiratory rate, and electromyography will be closely monitored while we are determining the correct stimulation parameters in the lab. During the stimulation training sessions, we will monitor blood pressure regularly throughout the session.

Locations (1)

Frazier Rehabilitation and Neuroscience Institute

Louisville, Kentucky, United States