Clinical Research Directory
Browse clinical research sites, groups, and studies.
Chronic Pain and Functional Prognosis After Total Knee Replacement: Continuous Locoregional Analgesia by Catheter to the Femoral Triangle Versus Tissue Infiltration as Part of an Improved Rehabilitation After Surgery Approach
Sponsor: Centre Hospitalier Departemental Vendee
Summary
The prevalence of Chronic Post-Surgical Pain (CPSP) after knee replacement, defined as pain greater than or equal to 4/10 on the visual analogue scale after the third postoperative month, is recognised as high, with an average of 20% (extremes of 7 to 45%). These CPSP, when present, cause poor long-term joint functional prognosis and impaired quality of life for patients. Many predictive, pre-, per- and post-operative factors of these CPSP have been identified in recent years. The most common postoperative risk factor found in the literature is the intensity of early pain. The treatment protocols for this early post-surgical pain are currently and mainly multimodal in nature, combining systemic analgesics (paracetamol, NSAIDs, morphine, gabapentins) and local anaesthetics, administered either in the form of peripheral nerve blocks (continuous or single injection) or in the form of tissue infiltration (TI) performed by the surgeon during the operation. Very few of these techniques have been evaluated for their ability to reduce the incidence of CPSP. Drugs with antihyperalgesic properties such as ketamine or nefopam have been shown to be of no interest, except to reduce the proportion of pain of a neuropathic nature. Only the continuous femoral block has shown, to date, an interest in IT to reduce the incidence of these CPSP. The main objective of this study is to show that a multimodal analgesia protocol based on continuous locoregional analgesia by femoral triangle catheterization could reduce the incidence of chronic post surgical pain compared to a protocol based on tissue infiltration.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
287
Start Date
2020-09-02
Completion Date
2024-04-08
Last Updated
2026-06-12
Healthy Volunteers
No
Conditions
Interventions
Ropivacaine
Locoregional analgesia by femoral triangle catheterization
Ropivacaine
Tissue infiltration
Locations (5)
Clinique Victor PAUCHET
Amiens, France
Centre Hospitalier de Béthune Beuvry
Béthune, France
Centre Hospitalier Départemental Vendée
La Roche-sur-Yon, France
Hôpital des Diaconesses Croix Saint Simon
Paris, France
Hôpital Privé Sévigné
Rennes, France