Clinical Research Directory

Inclusion Criteria: * Preterm Infants \< 32 wGA (weeks of gestational age) * Presenting a RDS (respiratory distress syndrome) * in the first 48 hours of life * treated by CPAP (continuous positive airway pressure) or BiPAP (Bilevel Positive Airway Pressure) * requiring surfactant : * FIO2 : (fraction of inspired oxygen) * if 28 - 31 SA : FiO2 ≥30% for a duration ≥ 10mn * if \<28 SA FIO2 ≥25% for a duration ≥10mn * SpO2 (arterial oxygen saturation) : to obtain a SpO2 between ≥88 and ≤ 95% * Available IntraVenous line (peripheral, umbilical or central catheter) * Recipient of the French Social Security * Informed consent form signed Exclusion Criteria: * Congenital and/or major malformations * FIO2 \>60% * Silverman score \>6 * Contraindication to the use of Propofol : * Low Blood Pressure with 2 successive measurements (Mean \< Gestational Age expressed in Weeks of Gestation) persisting after one volume expansion, * Use of inotropic medication to maintain a normal blood pressure. * Use of sedative or analgesic drugs (except paracetamol and ibuprofen) in the previous 24h * Coma, convulsions, areactivity at neurological examination