Clinical Research Directory

Inclusion Criteria: Part 1 - Eligibility Criteria for Neoadjuvant Chemotherapy * Patients must have histologically confirmed invasive cervical cancer with adenocarcinoma, adenosquamous or squamous histology and FIGO 2018 IB2 measuring \>2 cm - ≤4 cm by radiological imaging (MRI). * Patients must be premenopausal and wish to preserve fertility. * At time of registration, patient may not have had any prior therapy to treat their cancer lesion. * Eastern Cooperative Group (ECOG) performance status ≤ 2. * Within 7 days of the proposed start of treatment, patients must have normal organ and marrow function. * No evidence of active uncontrolled infection (patients on antibiotics are eligible). * Patient must have disease that is measurable per the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1. * Ability to understand and willing to sign a written informed consent document. * Patients must agree to use effective contraceptive methods prior to study entry, during study participation, and for at least one year after the fertility-sparing surgery (FSS) procedure. A serum pregnancy test within 72 hours prior to study registration is required. Part 2 - Eligibility Criteria for Fertility Sparing Surgery (FSS) * Completed 3 cycles of neo-adjuvant chemotherapy and achieved a complete response (CR) or partial response (PR) with reduction of the lesion to \<2 cm on physical examination and MRI. Exclusion Criteria: Part 1 - Exclusion Criteria for Neoadjuvant Chemotherapy * Patients who have had chemotherapy or radiotherapy or surgery for their cancer. * Patients who are receiving any other investigational agents. * Patients with other cancers requiring ongoing treatment. * Patients with known / evidence of brain metastases are excluded from participation in this clinical trial. * History of allergic reactions attributed to compounds of similar chemical or biologic composition to paclitaxel, carboplatin, or cisplatin or other agents used in study. * Uncontrolled inter-current illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * Patients who are pregnant or breastfeeding * Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns or compliance with clinical study procedures, e.g., infection/inflammation, intestinal obstruction, unable to swallow medication, social/ psychological issues. Part 2 - Exclusion Criteria for Fertility Sparing Surgery * Patient unable to complete 3 cycles of neoadjuvant chemotherapy * Suboptimal response to neoadjuvant chemotherapy according to investigator * Residual lesion \> 2cm or disease progression while on chemotherapy