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Screening of Gastric Cancer Via Breath Volatile Organic Compounds by Hybrid Sensing Approach
Sponsor: University of Latvia
Summary
The study is aimed to determine the potential of volatile marker testing for gastric cancer screening. The study will be addressing the role of confounding factors, including lifestyle factors, diet, smoking as well as addressing the potential role of microbiota in the composition of exhaled volatile markers.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
5000
Start Date
2019-11-01
Completion Date
2026-12
Last Updated
2021-07-26
Healthy Volunteers
Not specified
Interventions
Breath sampling for VOC detection
Breath sampling will be performed by using a special sensor device and or GC-MS analysis (by collecting breath samples in adsorbent tubes). Pepsinogen testing will be used in a subgroup to identify serological increased risk for atrophy
Surgery material collection for VOC headspace analysis
Only for gastric cancer patients undergoing surgery (Group 1)
Upper endoscopy
Routine endoscopic evaluation with a standard biopsy work-up according to updated Sydney system. Additional gastric contents for GC-MS and microbiota analysis in a subgroup. Endoscopy will be used only according to the clinical indications (in Group 4 - according to the results of pepsinogen tests)
Microbiota testing
Faecal and gastric contents and biopsy samples for microbiota testing
Locations (5)
A.C.Camargo Cancer Center
São Paulo, Brazil
Pontificia Universidad Catolica de Chile
Santiago, Chile
Centro Javeriano de Oncología, San Ignacio University Hospital
Bogotá, Colombia
Institute of Clinical and Preventive Medicine, University of Latvia
Riga, Latvia
National Cancer Institute of Ukraine
Kiev, Ukraine