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Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Sponsor: Wake Forest University Health Sciences
Summary
The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.
Key Details
Gender
All
Age Range
22 Years - 33 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2020-09-02
Completion Date
2026-06
Last Updated
2026-04-01
Healthy Volunteers
Yes
Conditions
Interventions
Allopurinol
Study Part 2- Preterm group only: After Visit 5 preterm born participants will start allopurinol 200 mg daily PO for 6 weeks. The 1 week high and low salt diets and assessments will be repeated while on allopurinol.
Dietary Intervention
High-Na+ (250 mmol/d) and low-Na+ (50 mmol/d) standard isocaloric K+ diets (75 mmol/1000 kcal/d) for 1 week each as 3 meals and 1 snack a day provided by the Clinical Research Unit Metabolic Kitchen. Part 2 preterm only- the diets will be repeated while the participant is taking allopurinol.
Locations (1)
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States