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Clarithromycin Mechanisms in Hypersomnia Syndromes
Sponsor: Emory University
Summary
The purpose of this study is to evaluate a medication called clarithromycin for treating sleepiness in narcolepsy and idiopathic hypersomnia. Studies have shown that clarithromycin can reduce sleepiness, but researchers do not know how clarithromycin does this. This study will look at brain activity (on magnetic resonance imaging \[MRI\]), inflammation, bacteria living in the gut, and cerebrospinal fluid, to better understand how clarithromycin can reduce sleepiness. This study will recruit 92 participants who will be randomized to receive clarithromycin or a placebo for 14 days.
Official title: Antibiotic-mediated Improvements in Vigilance: Mechanisms of Action of Clarithromycin in Hypersomnia Syndromes
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
83
Start Date
2019-09-04
Completion Date
2025-06-18
Last Updated
2026-08-07
Healthy Volunteers
No
Interventions
Clarithromycin
Clarithromycin will be dosed as 500 mg twice daily, once upon awakening and once with lunch, for 14 days.
Placebo
A placebo to match clarithromycin will be dosed as 500 mg twice daily, once upon awakening and once with lunch, for 14 days.
Locations (1)
Emory Sleep Center
Atlanta, Georgia, United States