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Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients
Sponsor: Nantes University Hospital
Summary
Infections on joint replacements remain one of the most serious complications of orthopaedic surgery. Despite improvements in skin preparation and antibiotic prophylaxis procedures, the risk of infection of joint prosthesis is still high, particularly for shoulder prostheses, especially in men. One of the bacteria most often involved in post-operative infections for shoulder prosthesis is Cutibacterium acnes (CA). This bacterium is one of the predominant bacteria in pilosebaceous units. Eradication of this micro-organism remains difficult despite the techniques used in the preoperative phase. The objective of this protocol is to evaluate the efficacy of applying a 5% benzoyl peroxide topical during the 5 days preceding the procedure in the surgical skin incision area, which is based on local acne treatment, on the reduction of the CA bacterial load in the dermis of the approach to shoulder arthroplasty in men.
Key Details
Gender
MALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2020-06-19
Completion Date
2029-06
Last Updated
2025-05-01
Healthy Volunteers
No
Conditions
Interventions
5% benzoyl peroxide
Application of 5% benzoyl peroxide during 5 days before the procedure
Locations (6)
CHU d'Angers
Angers, France
CHU de Brest
Brest, France
CHU de Limoges
Limoges, France
CHU de Nantes
Nantes, France
CHU de Rennes
Rennes, France
CHU de Tours
Tours, France