Clinical Research Directory

Inclusion Criteria: Patients with haemodynamically significant perimembranous defects which are located in the ventricular septum Exclusion Criteria: Occlutech® PmVSD Occluder is contraindicated for the following: * Patients with defects less than 2 mm aortic rim and/or interference with the aortic or atrioventricular valves * Patients less than 10.0 kg * Patients with sepsis (local or generalized) * Patients with left ventricle to right atrial shunting * Patients with right to left shunting through the defect * Patients with PmVSD with an aneurysm and multiple shunts that could not be successfully closed with one device * Patients with complex heart lesions such as tetralogy of fallot * History of repeated pulmonary infection * Any type of serious infection 1 month prior to procedure * Malignancy where life expectancy is less than 3 years * Demonstrated intracardiac thrombi on echocardiography * Patients with allergy to anti-platelet or anticoagulant therapy * Patients with allergy to nickel and/or titanium and/or nickel/titanium based materials * Patients with intolerance to contrast agents * Patients with active bacterial infections * Patients with very small vessels which are not suitable for recommended delivery sheath sizes