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Local Anesthetic Response in Ehlers-Danlos Syndrome (EDS) and Healthy Volunteers
Sponsor: Vanderbilt University Medical Center
Summary
Local anesthetic resistance is commonly reported by patients with EDS. However, there are no objective data on the occurrence of local anesthetic resistance in EDS patients and in healthy volunteers. We propose to collect such objective data on the frequency of drug resistance and whether any problems with local anesthesia are due to initial ineffectiveness or due to its effects dissipating too soon.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
230
Start Date
2019-07-26
Completion Date
2029-12-31
Last Updated
2025-10-14
Healthy Volunteers
Yes
Conditions
Interventions
0.9% Sodium Chloride Injection
All participants will be injected subcutaneously with a single 0.5ml dose
Lidocaine Injection 2%
All participants will be injected subcutaneously with a single 0.5ml dose
Bupivacaine Injection 0.5%
All participants will be injected subcutaneously with a single 0.5ml dose
Locations (1)
Vanderbilt University Medical Center
Nashville, Tennessee, United States