Clinical Research Directory

Inclusion Criteria: * Patients must have a histologically or cytologically confirmed Grade II or III soft tissue sarcoma that is considered to be resectable and are candidates for pre-op radiation. * Age greater than or equal to 18 years. No children will be enrolled on this protocol. * Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2. * Women of child-bearing potential and men must agree to use adequate contraception (hormonal or double-barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Patients taking concurrent hormonal therapy, biologic or other chemotherapy are excluded except women on hormonal contraceptives. * Patients taking an investigational agent are excluded. * Pregnant and nursing women are excluded. * Patients who require amputation for local control. * Patients who underwent unplanned excision or other previous surgery involving the affected extremity. * Patients with sarcoma subtypes for which established chemotherapeutic regimens exist. * History of radiation to the limb.