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Imaging Synapses With [11C] UCB-J in the Human Brain
Sponsor: Davidzon, Guido, M.D.
Summary
The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer \[11C\]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia. This imaging method allows for the quantification of synaptic density in the living human brain and has the unprecedented ability to directly examine the synaptic pathology underlying neuropsychiatric disease. The neural synaptic pruning hypothesis posits that a key pathogenic process of schizophrenia is the over-exuberant elimination of neural synapses during development. The confirmation of reduced synaptic density in schizophrenia as evidenced by \[11C\]UCB-J has the potential to lead to a number of ground-breaking clinical innovations, such as laboratory-based diagnostics and prognostics, and novel, disease-modifying treatments.
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2019-08-01
Completion Date
2025-12
Last Updated
2024-12-16
Healthy Volunteers
Yes
Conditions
Interventions
[11C]UCB-J radiotracer
I.V. bolus administration of up to 15 mCi (equivalent to 0.3 rems) in the antecubital vein
PET-MR
Positron emission tomography and magnetic resonance imaging, with a scan duration of up to 120 minutes
Locations (2)
VA Palo Alto Health Care System
Palo Alto, California, United States
Stanford University
Stanford, California, United States