Clinical Research Directory

Inclusion Criteria: * All subjects must be over between 18-65 years of age. * Must have confirmed diagnosis of severe Major Depressive Disorder (single or recurrent episode). * Failure to respond to a minimum of 4 trials of antidepressant medication * Failure to respond from at least two different agent classes * Accompanied by at least two evidence-based augmentation therapies (Benzodiazepines do not count). * Must have a trial of psychotherapy known to be effective in the treatment of MDD of an adequate frequency and duration. * Subjects are willing and able to adhere to the treatment schedule and required study visits Exclusion Criteria: * Are mentally or legally incapacitated, unable to give informed consent * Have an infection or poor skin condition over the scalp where the device will be positioned * Have increased risk of seizure because of family history, stroke, or currently use medications that lead to increased risk for seizure * Diagnosis of acute or chronic psychotic symptoms or disorders (such as schizophrenia, schizophreniform or schizoaffective disorder) in the current depressive episode. * Neurological conditions that include epilepsy, cerebrovascular disease, dementia, increased intracranial pressure, having a history of repetitive or severe head trauma, or with primary or secondary tumors in the central nervous system. * Presence of an implanted magnetic-sensitive medical device located less than or equal to 30 centimeters from the transcranial magnetic stimulation magnetic coil or other implanted metal items, including but not limited to a cochlear implant, implanted cardioverter defibrillator, pacemaker, vagus nerve stimulator, or metal aneurysm clips or coils, staples, or stents. (Note: Dental amalgam fillings are not affected by the magnetic field and are acceptable for use with transcranial magnetic stimulation