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High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease
Sponsor: Massachusetts Institute of Technology
Summary
Alzheimer's disease (AD) is characterized by significant memory loss and toxic protein deposits (amyloid and tau) in the brain. The investigators' lab found a non-invasive way to remove these toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators aim to translate this non-invasive method, which uses light and sound to stimulate the brain, to be used in mild Alzheimer's patients. 40 participants with mild Alzheimer's disease will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) before, during, and after light and sound stimulation for safety, feasibility, and to optimize the stimulation device for use in the mild AD population.
Official title: Acute Treatment of Alzheimer's Disease With Gamma Frequency Stimulation
Key Details
Gender
All
Age Range
50 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2019-04-19
Completion Date
2027-04-30
Last Updated
2024-10-01
Healthy Volunteers
No
Conditions
Interventions
GENUS device (Active Settings)
Participants in the experimental group will use the GENUS device configured to active settings for 30 - 60 minutes.
GENUS device (Sham Settings)
Participants in the control group will use the GENUS device configured to sham settings for 30 - 60 minutes.
Locations (1)
Massachusetts Institute of Technology
Cambridge, Massachusetts, United States