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ACTIVE NOT RECRUITING
NCT04042922
NA

High Frequency Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease

Sponsor: Massachusetts Institute of Technology

View on ClinicalTrials.gov

Summary

Alzheimer's disease (AD) is characterized by significant memory loss and toxic protein deposits (amyloid and tau) in the brain. The investigators' lab found a non-invasive way to remove these toxic proteins from the brain in AD mouse models. Remarkably, treated mice also have improved memory on behavioral testing. The investigators aim to translate this non-invasive method, which uses light and sound to stimulate the brain, to be used in mild Alzheimer's patients. 40 participants with mild Alzheimer's disease will be recruited, and the investigators will assess their brain waves with electroencephalogram (EEG) before, during, and after light and sound stimulation for safety, feasibility, and to optimize the stimulation device for use in the mild AD population.

Official title: Acute Treatment of Alzheimer's Disease With Gamma Frequency Stimulation

Key Details

Gender

All

Age Range

50 Years - 100 Years

Study Type

INTERVENTIONAL

Enrollment

80

Start Date

2019-04-19

Completion Date

2027-04-30

Last Updated

2024-10-01

Healthy Volunteers

No

Interventions

DEVICE

GENUS device (Active Settings)

Participants in the experimental group will use the GENUS device configured to active settings for 30 - 60 minutes.

DEVICE

GENUS device (Sham Settings)

Participants in the control group will use the GENUS device configured to sham settings for 30 - 60 minutes.

Locations (1)

Massachusetts Institute of Technology

Cambridge, Massachusetts, United States