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Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage
Sponsor: Insel Gruppe AG, University Hospital Bern
Summary
Patients with subarachnoid hemorrhage are prone to suffer from dysnatriemia. Evidence shows that hyponatriemia is associated with increased incidence of vasospasm, brain swelling and mortality in these patients. Patients with subarachnoid hemorrhage often require large amounts of iv fluids in order to maintain euvolemia and support cardiocirculatory function. Prior evidence shows that the type of infusion fluid significantly influences blood sodium content. Hence, this study evaluated whether the sodium content of the infusion solution impacts mortality and morbidity in patients with subarachnoid hemorrhage.
Official title: Crystalloid Fluid Choice and Neurological Outcome in Patients After Subarachnoid Haemorrhage - a Multi-center Randomized Double-blind Clinical Trial
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
INTERVENTIONAL
Enrollment
320
Start Date
2022-05-24
Completion Date
2026-07
Last Updated
2025-12-18
Healthy Volunteers
No
Interventions
0.9% Sodium-chloride
We will compare two already established treatment protocols: the use of normal saline versus lactated Ringer's for fluid therapy in patients with subarachnoid hemorrhage.
Ringer's Lactate
We will compare two already established treatment protocols: the use of normal saline versus lactated Ringer's for fluid therapy in patients with subarachnoid hemorrhage.
Locations (3)
Department of perioperative Intensive Care Medicine
Sankt Gallen, Canton of St. Gallen, Switzerland
Department of Intensive Care, Bern University Hospital and University of Bern, Bern, Switzerland
Bern, Switzerland
Department of Intensive Care Medicine
Geneva, Switzerland