Clinical Research Directory

Inclusion Criteria: 1. Women between 2 and 5 years after menopause, without hormone therapy for at least 2 years 2. To present, at least moderate, or severe intensity (score 4 or more of visual analog scale ( 0-10)) of one of the signs or symptoms of of vulvovaginal atrophy: * Burning * Discomfort * Dryness * Cracks * Pruritus * Lack of vaginal lubrication * Penetration dyspareunia that began at the menopausal or postmenopausal transition * Decreased vaginal epithelium turgor and trophism * Deletion of mucous and skin folds. The Exclusion criteria will be: 1. Active genital infection, active infection of HPV (human papillomavirus) or Herpes, users of medications with estrogenic effect (digoxin, tamoxifen and other chemicals) 2. Postmenopausal genital bleeding, uncontrolled diabetes, use of multivitamins with zinc, use of copper or hormonal IUDs (intrauterine device) at the time of inclusion, presence of genitourinary or rectovaginal fistulas.