Clinical Research Directory

Inclusion Criteria: * Diagnosis of MS * Evidence of sleep disturbance * Stable on immunomodulatory MS therapy or no therapy for at least 6 months prior to study initiation * Stable on antidepressants for at least 3 months prior to study initiation and no evidence * Stable on fatigue medication for at least 3 months prior to study initiation * Willing and able to provide informed consent and follow study procedures. Exclusion Criteria: * Evidence of cognitive impairment * Low risk for sleep disordered breathing * Other comorbid ophthalmologic disorders (e.g. cataracts, glaucoma, blindness) * Traveled across two time zones within 90 days of study screening. * Not participating in shift work * MS relapse or history of acute optic neuritis within 30 days * No prior history of bipolar disorder * No evidence of current depression * Diagnosis of severe periodic limb movement disorder or severe restless legs syndrome