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Longitudinal Evaluation of Microbial and Host Signatures During Immunotherapy for Lung Cancer
Sponsor: NYU Langone Health
Summary
This study will prospectively collect airway, stool, and blood samples on 80 subjects with lung cancer undergoing immunotherapy. Investigators will evaluate airway/stool microbial signatures associated with local (lower airway) and systemic (blood) immune tone.They will then study whether microbiota and/or host signatures predict subjects' response by longitudinal assessment of the progression free survival. They will also repeat sampling after 8 weeks of immunotherapy to expand our mechanistic understanding of the response to treatment.
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
48
Start Date
2021-02-09
Completion Date
2027-02
Last Updated
2025-12-02
Healthy Volunteers
No
Conditions
Interventions
Bronchoscopy
The patient will then return within a week for a research bronchoscopy to sample the upper and lower airways
Research Procedures
electrocardiogram, blood work (CBC, chemistry, coagulation profile and liver function tests, pregnancy test if applicable), X-ray and pulmonary function (spirometry) testing, and provide the patient with a stool collection kit.
Locations (1)
NYU Langone Health
New York, New York, United States