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SMART-EST(Specialized Multi-center Attributed Registry of sTroke - EndovaScular or Thrombolytic Therapy)
Sponsor: Yonsei University
Summary
Use of intravenous(IV) thrombolysis and intra-arterial(IA) recanalization treatment has been rapidly increasing, However, despite of the treatment, recanalization rates are 22.6 - 70% and only 30-50% of patients show meaningful clinical improvements. Mechanisms of futile recanalization may include 1) large ischemic core, 2) poor collateral, and 3) presence of comorbidity. In this regards, developing selection criteria using acute stroke imaging and comorbidity is warranted. The investigators will recruit the consecutive acute stroke patients who received IV thrombolysis and/or IA recanalization treatment. This study will perform with prospective design to develop CT-based clot, core and collateral scores and a comorbidity index for selecting stroke patients who are at high risks by the treatment. The investigators will firstly establish the CT-based scores and comorbidity index using a pre-existing cohort database. Using these CT-based and comorbidity index, the investigators will validate them in a multi-center prospectively cohort.
Official title: Prospective Multicenter Registry for Acute Ischemic Stroke Patients With Standard Reperfusion Therapy
Key Details
Gender
All
Age Range
20 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
5000
Start Date
2019-07-12
Completion Date
2029-06
Last Updated
2019-08-28
Healthy Volunteers
No
Conditions
Interventions
Brain CT imaging
The investigators will analyzed the CT image that was performed in patients with hyperacute stroke. The CT protocol includes CT thrombus, collateral, core images. The investigators also obtain detailed history and laboratory and imaging result for comorbidity. The comorbidity index protocol is based on the Charlson comorbidity index. * Cut-off values in thrombus volume and Hounsfield unit according to non-contrast CT images * Cut-off values in areas of irreversible changes according to non-contrast CT images * Cut-off values in occlusion sites and collateral scores according to CT angiographies * Cut-off values of consolidated CT imaging index including clot, core, and collateral score * Cut-off values of comorbidity index * Medical care expenses according to comorbidity index in patients who received intravenous thrombolytic treatment and/or endovascular recanalization treatments.
Locations (1)
Department of Neurology, Yonsei University College of Medicine
Seoul, South Korea