Clinical Research Directory

Inclusion Criteria: * Adolescent (e) consultant for very large size with a demand for growth inhibition * Very large idiopathic or secondary height without any other etiological treatment possible * Tanner score ≥ 3 for boys and ≥ 2 for girls * A0 ≤ 14 years for boys and ≤ 12.5 years for girls * A chronological age of 10 to 16 for boys and 8 to 14 for girls * Actual size from minimum 167.5 cm to 10 years old to at least 180 cm to 16 years old for boys and from minimum 160 cm to 8 years old to at least 174 cm to 14 years old for girls * Predicted height ≥ 198 cm for boys and ≥ ≥ 184 cm for girls (refer to chapter 6.6) * Radiological persistence of tibial and femoral tibial cartilage estimated residual growth ≥ 8 cm * Absence of psychological contraindication to a curbing treatment of growth * Agreement of the holders of the parental authority and the teenager for a surgery of epiphysiodesis type * Agreement of the holders of the parental authority and the teenager to take part in the study * Affiliated to a social security scheme Exclusion Criteria: * Very large size related to a medically curable etiology (hypersecretion of growth hormone called acromegaly) * Refusal of the holders of the parental authority or the teenager for a surgery of the epiphysiodesis type * Refusal of the holders of the parental authority or the teenager to take part in the study * Medical or psychological contraindication to surgery.