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Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Sponsor: Jessa Hospital
Summary
In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well. The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2019-09-01
Completion Date
2026-10-30
Last Updated
2021-08-25
Healthy Volunteers
Not specified
Interventions
vestibular test 1
videonystagmography
vestibular test 2
video head impulse test
vestibular evoked myogenic potentials
vestibular evoked myogenic potentials to measure the function of otolith organs
audiometry
tonal liminar audiometric thresholds
CT and MR imaging of temporal bone
Ct and MR imaging of temporal bone
p.P51S mutation
analysis of presence of p.P51S mutation in COCH
Locations (1)
Jessa Hospital
Hasselt, Limburg, Belgium