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PET Imaging of Giant Cell and Takayasu Arteritis
Sponsor: University of Cambridge
Summary
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging is often included in the diagnostic work-up of patients with large-vessel vasculitis (LVV), 18F-FDG lacks specificity for inflammatory cells and has limited ability to track therapy response. Moreover, high background 18F-FDG uptake in the brain and myocardium largely precludes imaging temporal arteritis in giant-cell arteritis (GCA) and coronary artery involvement in Takayasu arteritis respectively. These limitations of 18F-FDG for imaging LVV highlight important unmet clinical needs, which might be overcome by using a somatostatin receptor subtype-2 (SST2) PET tracer.
Official title: The PET Imaging of Giant Cell and Takayasu Arteritis Study
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
27
Start Date
2019-06-25
Completion Date
2025-04
Last Updated
2024-07-22
Healthy Volunteers
No
Conditions
Interventions
PET-MRI
SST2 PET-MRI scan
Locations (2)
University of Cambridge
Cambridge, Cambridgeshire, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom