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Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
Sponsor: University Hospital, Bordeaux
Summary
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
Official title: Involvement of Matrix Metalloproteinases and Association With the Expression of Human Papillomavirus in Dysplasias and Cancers of the Cervix
Key Details
Gender
FEMALE
Age Range
20 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
216
Start Date
2007-10-10
Completion Date
2011-01-31
Last Updated
2026-06-17
Healthy Volunteers
No
Interventions
Vaginal samples (biopsies + vaginal smear)
Two types of samples are envisaged: tissue (large biopsies, coin of conization or hysterectomy) to affirm the diagnosis and detect the matrix metalloproteinases and their tissue inhibitors by immunohistochemistry; cell sample (monolayer smear type) to evaluate the expression of oncogenic Human papillomavirus.