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NCT04072913
NA

Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix

Sponsor: University Hospital, Bordeaux

View on ClinicalTrials.gov

Summary

This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.

Official title: Involvement of Matrix Metalloproteinases and Association With the Expression of Human Papillomavirus in Dysplasias and Cancers of the Cervix

Key Details

Gender

FEMALE

Age Range

20 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

216

Start Date

2007-10-10

Completion Date

2011-01-31

Last Updated

2026-06-17

Healthy Volunteers

No

Interventions

OTHER

Vaginal samples (biopsies + vaginal smear)

Two types of samples are envisaged: tissue (large biopsies, coin of conization or hysterectomy) to affirm the diagnosis and detect the matrix metalloproteinases and their tissue inhibitors by immunohistochemistry; cell sample (monolayer smear type) to evaluate the expression of oncogenic Human papillomavirus.