Clinical Research Directory

Inclusion Criteria for MCI/Mild AD Participant: * Subject has diagnosis of amnestic mild cognitive impairment (MCI) or mild Alzheimer's disease (AD), as defined by a Montreal Cognitive Assessment (MoCA) score between 17 and 24 and those who fall between 0.5-4.0 and 4.5-9.0 in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SOB) instrument * Subject has sleep disturbance indicated by a score \>5 on the Pittsburgh Sleep Quality Index and sleep efficiency below 80% as indicated via actigraphy * Subject resides in his/her home, independent living, or assisted living facilities with a caregiver. Exclusion Criteria for MCI/Mild AD Participant: * Subject diagnosed with another brain disease that fully explains the dementia (extensive brain vascular disease, Parkinson's disease, dementia with Lewy bodies, traumatic brain injury, or multiple sclerosis) * Subject resides in a skilled nursing facility or long-term care * Subject has had recent changes in psychotropics (14 days) * Subject has major organ failure (e.g., kidney failure) * Subject has uncontrolled generalized disorders such as hypertension or diabetes * Subject has obstructing cataracts, macular degeneration, and/or blindness * Subject has undergone cataract surgery and received an intraocular lens coated with ultraviolet- and blue-blocking filters (400-440/440-500 nm) * Subject diagnosed with severe sleep apnea; using the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ) the study will use a score of 29 as a cutoff for men and a cutoff of 26 for women * Subject diagnosed with restless leg syndrome (RLS); using the International Restless Legs Scale (IRLS), the study will use a cutoff of ≥11 as a positive screen for RLS * Subject has a history of severe photosensitivity dermatitis, severe progressive retinal disease (e.g., macular degeneration), or a permanently dilated pupil (e.g., after certain types of cataract surgery) For caregivers, we will accept those who: * Live with the patients * Are not diagnosed with dementia (MOCA between 25 and 30 and CDR=0) * Understand English * Are willing to help with the study * No other inclusion/exclusion criteria will be used for enrolling caregivers. There is no age requirement for caregivers.