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ACTIVE NOT RECRUITING
NCT04073810

Residual Inflammation and Plaque Progression Long-term Evaluation

Sponsor: University of Cambridge

View on ClinicalTrials.gov

Summary

Inflammation drives atherosclerotic plaque rupture triggering most acute coronary syndromes. Despite advances in diagnosis and management of atherosclerosis, patients with myocardial infarction (MI) remain at increased risk of recurrent events. The RIPPLE study aims to examine the relationship between residual coronary inflammation detected by 68Ga-DOTATATE PET in patients treated for MI to long-term plaque progression measured by CT coronary angiography (CTCA). The association between infarct-related myocardial 68Ga-DOTATATE PET and myocardial function and viability will also be assessed.

Key Details

Gender

All

Age Range

18 Years - 99 Years

Study Type

OBSERVATIONAL

Enrollment

40

Start Date

2020-10-01

Completion Date

2025-04-01

Last Updated

2024-07-19

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

PET imaging

Coronary 68Ga-DOTATATE PET-MRI or PET-CT at baseline and 3 months

DIAGNOSTIC_TEST

Coronary CT angiography

CTCA at baseline and 2 years

DIAGNOSTIC_TEST

Cardiac MRI

Cardiac MRI at 1 year

Locations (1)

University of Cambridge

Cambridge, United Kingdom