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Residual Inflammation and Plaque Progression Long-term Evaluation
Sponsor: University of Cambridge
Summary
Inflammation drives atherosclerotic plaque rupture triggering most acute coronary syndromes. Despite advances in diagnosis and management of atherosclerosis, patients with myocardial infarction (MI) remain at increased risk of recurrent events. The RIPPLE study aims to examine the relationship between residual coronary inflammation detected by 68Ga-DOTATATE PET in patients treated for MI to long-term plaque progression measured by CT coronary angiography (CTCA). The association between infarct-related myocardial 68Ga-DOTATATE PET and myocardial function and viability will also be assessed.
Key Details
Gender
All
Age Range
18 Years - 99 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2020-10-01
Completion Date
2025-04-01
Last Updated
2024-07-19
Healthy Volunteers
No
Interventions
PET imaging
Coronary 68Ga-DOTATATE PET-MRI or PET-CT at baseline and 3 months
Coronary CT angiography
CTCA at baseline and 2 years
Cardiac MRI
Cardiac MRI at 1 year
Locations (1)
University of Cambridge
Cambridge, United Kingdom